Amyloidogenicroleofcytokine TGF - b 1 in transgenicmiceand inAlzheimer ’ sdisease

نویسندگان

  • Tony Wyss-Coray
  • Eliezer Masliah
  • Margaret Mallory
  • Lisa McConlogue
  • Kelly Johnson-Wood
  • Carol Lin
  • Lennart Mucke
چکیده

NATURE | VOL 389 | 9 OCTOBER 1997 603 20. Korczak, B. et al. cDNA cloning and functional properties of human glutamate receptor EAA3 (GluR5) in homomeric and heteromeric configuration. Recept. Chann. 3, 41–49 (1995). 21. Huettner, J. E. Glutamate receptor channels in rat DRG neurons: Activation by kainate and quisqualate and blockade of desensitization by Con A. Neuron 5, 255–266 (1990). 22. Partin, K. M., Patneau, D. K., Winters, C. A., Mayer, M. L. & Buonanno, A. Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A. Neuron 11, 1069–1082 (1993). 23. Bleakman, D. et al. Pharmacological discrimination of GluR5 and GluR6 kainate receptor subtypes by (3S, 4aR, 6R, 8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinoline-3 carboxylic-acid. Mol. Pharmacol. 49, 581–585 (1996). 24. Davies, S. N. & Collingridge, G. L. Role of excitatory amino acid receptors in synaptic transmission in area CA1 of rat hippocampus. Proc. R. Soc. Lond. B 236, 373–384 (1989). 25. Paternain, A. V., Morales, M. & Lerma, J. Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons. Neuron 14, 185–189 (1995). 26. Chittajallu, R. et al. Regulation of glutamate release by presynaptic kainate receptors in the hippocampus. Nature 379, 78–81 (1996). 27. Wilding, T. J. & Huettner, J. E. Differential antagonism of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-preferring and kainate-preferring receptors by 2,3-benzodiazepines. Mol. Pharmacol. 47, 582–587 (1995). 28. Partin, K. M. & Mayer, M. L. Negative allosteric modulation of wild-type and mutant AMPA receptors by GYKI53655. Mol. Pharmacol. 49, 142–148 (1996). 29. Bleakman, D. et al. Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: Stereospecificity and selectivity profiles. Neuropharmacology 35, 1689–1702 (1996). 30. Davies, C. H., Pozza, M. F. & Collingridge, G. L. CGP55845A: A potent antagonist of GABAB receptors in the CA1 region of the rat hippocampus. Neuropharmacoogy 32, 1071–1073 (1993).

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تاریخ انتشار 1997